There is no association between autosomal dominant polycystic kidney disease and left ventricular non-compaction cardiomyopathy: a cardiac magnetic resonance imaging study

Background Autosomal dominant polycystic kidney disease (ADPKD) is the most common familial renal disorder. Left ventricular non-compaction cardiomyopathy (LVNC) is a rare cardiac condition resulting primarily from interruption of the normal embryonic process of myocardial compaction. Genes responsible for ADPKD have been linked to disorganized myocardial arrangement in animal models. In addition, there are multiple published case reports of ADPKD and LVNC occurring in the same patient. Therefore, we sought to examine possible association of ADPKD with LVNC in a large cohort of patients using cardiac magnetic resonance (CMR) imaging.